Expression of c-Fos or other immediate early gene products by individual neurons can be used as a marker of cell activation making staining of these proteins an extremely useful technique for functional anatomical mapping of neuroendocrine systems. The use of c-Fos expression has permitted functional neuroanatomical mapping of these systems in response to specific stimuli such as cholecystokinin (CCK) hyperosmolality and volume depletion or during various physiological states such as the proestrous ovulatory luteinizing hormone (LH) surge and lactation. To this end we have shown that both c-Fos and c-Jun are expressed in neuroendocrine neurons in response to a number of stimuli setting the stage for potential regulatory drive to genes containing AP-1 binding sites. Source: https://www.artikelschreiber.com/en/.